HCID 20398593, compound → HCID 20398592, compound

HRID 325620Notes

Reaction equation

HRID 325620 reaction equation
[C:1]1([N:7]2[CH:11]([C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=3)[CH2:10][C:9](=[O:18])[N:8]2[CH2:19][CH2:20][CH2:21][N:22]2[CH2:27][CH2:26][N:25](C=O)[CH2:24][CH2:23]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1>C(O)C.Cl>[C:1]1([N:7]2[CH:11]([C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=3)[CH2:10][C:9](=[O:18])[N:8]2[CH2:19][CH2:20][CH2:21][N:22]2[CH2:27][CH2:26][NH:25][CH2:24][CH2:23]2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

4

Reactant 1

HCID 20398593HCID 20398593, compound

Product 1

HCID 20398592HCID 20398592, compound

Reagents, catalysts & solvents 2

HCID 313Hydrochloric AcidSolventHCID 702EthanolSolvent

Procedure

19.2 g of 1,5-diphenyl-2-[3-(4-formylpiperazin-1-yl)-propyl]-pyrazolin-3-one are dissolved in 200 ml of a mixture of ethanol and 20% strength hydrochloric acid (1:1). The solution is left to stand at room temperature for 12 hours and is then heated under reflux for another 2 hours, and the ethanol is then distilled off in vacuo. Toluene and dilute sodium hydroxide solution are added to the residue. The toluene phase is separated off, washed with water, dried over sodium sulphate and evaporated in vacuo. 1,5-Diphenyl-2-[3-(piperazin-1-yl)-propyl]-pyrazolin-3-one is obtained as the residue.

Workup

  1. waitThe solution is left
  2. temperatureis then heated
  3. temperatureunder reflux for another 2 hours
  4. distillationthe ethanol is then distilled off in vacuo
  5. additionToluene and dilute sodium hydroxide solution are added to the residue
  6. customThe toluene phase is separated off
  7. washwashed with water
  8. dry with materialdried over sodium sulphate
  9. customevaporated in vacuo

Sources & evidence

ORD record
ord-ef7d946c5c0c4468b4f25b5d2bc46d9d
Source dataset
uspto-grants-1984_04
Patent number
US04442102

Reaction notes

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