Formaldehyde → HCID 178519811, compound

HRID 325625Notes

Reaction equation

HRID 325625 reaction equation
[OH:1][C:2]1[C:11]2[C:6](=[CH:7][C:8]([C:12]([F:15])([F:14])[F:13])=[CH:9][CH:10]=2)[N:5]=[CH:4][CH:3]=1.[CH2:16]=[O:17]>[OH-].[Na+]>[OH:1][C:2]1[C:11]2[C:6](=[CH:7][C:8]([C:12]([F:15])([F:13])[F:14])=[CH:9][CH:10]=2)[N:5]=[CH:4][C:3]=1[CH2:16][OH:17]

Participants

4

Reactant 2

HCID 712FormaldehydeHCID 178516425HCID 178516425, compound

Product 1

HCID 178519811HCID 178519811, compound

Reagents, catalysts & solvents 1

HCID 14798Sodium HydroxideSolvent

Procedure

A mixture of 4-hydroxy-7-trifluoromethylquinoline (30.0 g.), 40% aqueous formaldehyde solution (36 ml.) and 1 M aqueous sodium hydroxide solution (250 ml.) was stirred at 40°-50° for 8 hours. The solid product was collected and dried to give the novel 4-hydroxy-3-hydroxymethyl-7-trifluoromethylquinoline, m.p. 302°-304°.

Workup

  1. customThe solid product was collected
  2. customdried

Sources & evidence

ORD record
ord-15329c99661a47ca995ee2271acef378
Source dataset
uspto-grants-1984_04
Patent number
US04442109

Reaction notes

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