反应详情

To a stirred solution of 1-methyl-3-methylthiomethyl-7-trifluoromethyl-4-quinolone (6.5 g.) in dichloromethane (150 ml.) at -10° was added a solution of 3-chloroperbenzoic acid (85%, 4.2 g.) in dichloromethane (90 ml.) during 30 minutes. The solution was extracted with saturated aqueous sodium bicarbonate until free of per-acid. The organic phase was dried over anhydrous magnesium sulphate and evaporated to give a solid product. This was crystallised from ethyl acetate:dichloromethane to give the novel 1-methyl-3-methylsulphinylmethyl-7-trifluoromethyl-4-quinolone, m.p. 208°-210°.

1. extractionThe solution was extracted with saturated aqueous sodium bicarbonate until free of per-acid
2. dry with materialThe organic phase was dried over anhydrous magnesium sulphate
3. customevaporated
4. customto give a solid product
5. customThis was crystallised from ethyl acetate