Formaldehyde → HCID 178519817, compound

HRID 325637Notes

Reaction equation

HRID 325637 reaction equation
[F:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:11]=1[N:10]=[CH:9][CH:8]=[C:7]2[OH:12].[CH2:13]=[O:14].ClCCl>[OH-].[Na+]>[F:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:11]=1[N:10]=[CH:9][C:8]([CH2:13][OH:14])=[C:7]2[OH:12]

Participants

5

Reactant 3

HCID 712FormaldehydeHCID 6344DichloromethaneHCID 178516458HCID 178516458, compound

Product 1

HCID 178519817HCID 178519817, compound

Reagents, catalysts & solvents 1

HCID 14798Sodium HydroxideSolvent

Procedure

8-Fluoro-4-hydroxyquinoline was reacted with formaldehyde in aqueous sodium hydroxide to give the novel compound 8-fluoro-4-hydroxy-3-hydroxymethylquinoline, m.p. 176°-178° (from dichloromethane).

Sources & evidence

ORD record
ord-38970286e84a46cb833b9fa2152239f6
Source dataset
uspto-grants-1984_04
Patent number
US04442109

Reaction notes

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