HCID 178435556, compound → HCID 178435553, compound

HRID 325642Notes

Reaction equation

HRID 325642 reaction equation
[CH2:1]([C:3]1[CH:12]=[C:11]2[C:6]([C:7]([OH:16])=[C:8](C(O)=O)[CH:9]=[N:10]2)=[CH:5][CH:4]=1)[CH3:2]>C1(OC2C=CC=CC=2)C=CC=CC=1>[CH2:1]([C:3]1[CH:12]=[C:11]2[C:6]([C:7]([OH:16])=[CH:8][CH:9]=[N:10]2)=[CH:5][CH:4]=1)[CH3:2]

Participants

3

Reactant 1

HCID 178435556HCID 178435556, compound

Product 1

HCID 178435553HCID 178435553, compound

Reagents, catalysts & solvents 1

HCID 7583Diphenyl EtherSolvent

Procedure

7-Ethyl-4-hydroxyquinoline-3-carboxylic acid (200.8 g.) was added portionwise during 70 minutes to boiling diphenyl ether (1.64 liters). The stirring mixture was cooled to room temperature and an equal volume of petroleum ether (b.p. 60°-80°) added. The brown solid was collected and crystallised from water to give the novel 7-ethyl-4-hydroxyquinoline m.p. 148°-152°.

Workup

  1. customThe brown solid was collected
  2. customcrystallised from water

Sources & evidence

ORD record
ord-df716b6b9cc24bab9877caee85b9db65
Source dataset
uspto-grants-1984_04
Patent number
US04442109

Reaction notes

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