Formaldehyde → HCID 178519815, compound

HRID 325645Notes

Reaction equation

HRID 325645 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:11]=1[N:10]=[CH:9][CH:8]=[C:7]2[OH:12].[CH2:13]=[O:14].CO>[OH-].[Na+]>[Cl:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:11]=1[N:10]=[CH:9][C:8]([CH2:13][OH:14])=[C:7]2[OH:12]

Participants

5

Reactant 3

HCID 712FormaldehydeHCID 887MethanolHCID 178516443HCID 178516443, compound

Product 1

HCID 178519815HCID 178519815, compound

Reagents, catalysts & solvents 1

HCID 14798Sodium HydroxideSolvent

Procedure

8-Chloro-4-hydroxyquinoline was reacted with formaldehyde in aqueous sodium hydroxide to give the novel compound 8-chloro-4-hydroxy-3-hydroxymethylquinoline, m.p. >300° (from methanol).

Sources & evidence

ORD record
ord-0a10780eddbb4c2f8da35ab09497dbe3
Source dataset
uspto-grants-1984_04
Patent number
US04442109

Reaction notes

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