Dimethyl Sulfate → HCID 12807841, compound

HRID 325656Notes

Reaction equation

HRID 325656 reaction equation
S(OC)(O[CH3:5])(=O)=O.[OH:8][C:9]1[C:18]2[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=2)[N:12]=[CH:11][C:10]=1[CH2:19][S:20]([CH3:23])(=[O:22])=[O:21].[OH-].[K+]>O>[CH3:5][N:12]1[C:13]2[C:18](=[CH:17][CH:16]=[CH:15][CH:14]=2)[C:9](=[O:8])[C:10]([CH2:19][S:20]([CH3:23])(=[O:22])=[O:21])=[CH:11]1

Participants

5

Reactant 3

HCID 6497Dimethyl SulfateHCID 14797Potassium HydroxideHCID 178504870HCID 178504870, compound

Product 1

HCID 12807841HCID 12807841, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Dimethyl sulphate (3.0 ml.) was added to a stirred solution of 4-hydroxy-3-methylsulphonylmethylquinoline (1.9 g.) and potassium hydroxide (1.4 g.) in water (20 ml.) at 5°. The mixture was stirred at room temperature for 4 hours, then filtered to give the novel 1-methyl-3-methylsulphonylmethyl-4-quinolone, m.p. 204°-205° (from acetone).

Workup

  1. filtrationfiltered

Sources & evidence

ORD record
ord-0c67c35d06b640c5b280cfd3568df434
Source dataset
uspto-grants-1984_04
Patent number
US04442109

Reaction notes

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