HCID 13457820, compound → HCID 23322143, compound

HRID 325666Notes

Reaction equation

HRID 325666 reaction equation
[CH2:1]([N:4]([CH2:20][CH2:21][CH3:22])[CH:5]1[CH2:14][CH2:13][C:12]2[C:7](=[CH:8][C:9]([N+:17]([O-])=O)=[C:10]([O:15][CH3:16])[CH:11]=2)[CH2:6]1)[CH2:2][CH3:3]>[Ni].C(O)C>[CH2:20]([N:4]([CH2:1][CH2:2][CH3:3])[CH:5]1[CH2:14][CH2:13][C:12]2[C:7](=[CH:8][C:9]([NH2:17])=[C:10]([O:15][CH3:16])[CH:11]=2)[CH2:6]1)[CH2:21][CH3:22]

Participants

4

Reactant 1

HCID 13457820HCID 13457820, compound

Product 1

HCID 23322143HCID 23322143, compound

Reagents, catalysts & solvents 2

HCID 935NickelCatalystHCID 702EthanolSolvent

Procedure

9 g of the 2-dipropylamino-6-methoxy-7-nitro-1,2,3,4-tetrahydronaphthalene obtained in accordance with Example 1(b) are introduced into 200 ml of ethanol, together with 1 g of Raney nickel. At ambient temperature, hydrogenation is carried out under pressure until the absorption has stopped. After evaporation of the solvent, an oil remains which is shown to oxidise fairly readily in air.

Workup

  1. customAt ambient temperature, hydrogenation is carried out under pressure until the absorption
  2. customAfter evaporation of the solvent

Sources & evidence

ORD record
ord-65641c9e69e64fafad009c26959a3ab8
Source dataset
uspto-grants-1984_04
Patent number
US04442126

Reaction notes

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