Acetic Acid → HCID 20463959, compound

HRID 325668Notes

Reaction equation

HRID 325668 reaction equation
[C:1]([OH:4])(=O)[CH3:2].C(OC(=O)C)(=O)C.[BrH:12].[CH2:13]([N:16]([CH2:29][CH2:30][CH3:31])[CH:17]1[CH2:26][CH2:25][C:24]2[C:19](=[CH:20][CH:21]=[C:22]([OH:28])[C:23]=2[NH2:27])[CH2:18]1)[CH2:14][CH3:15].C(OCC)C>C(Cl)Cl>[BrH:12].[CH2:29]([N:16]([CH2:13][CH2:14][CH3:15])[CH:17]1[CH2:26][CH2:25][C:24]2[C:19](=[CH:20][CH:21]=[C:22]([OH:28])[C:23]=2[NH:27][C:1](=[O:4])[CH3:2])[CH2:18]1)[CH2:30][CH3:31]

Participants

6

Reactant 4

HCID 176Acetic AcidHCID 3283Diethyl EtherHCID 7918Acetic AnhydrideHCID 23322139HCID 23322139, compound

Product 1

HCID 20463959HCID 20463959, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

10 ml of acetic acid and 0.46 ml of acetic anhydride are added to 1.5 g of 2-dipropylamino-5-amino-6-hydroxy-1,2,3,4-tetrahydronaphthalene hydrobromide (obtained in accordance with Example 1(d)) in 25 ml of methylene chloride at 0° C. The mixture is stirred for one hour, diethyl ether is added and the solid is recrystallised from ethanol. This gives 1.2 g of a product melting at 244.5° C.

Workup

  1. customthe solid is recrystallised from ethanol

Sources & evidence

ORD record
ord-9dcde48363744fd7bcfb1563b39f2788
Source dataset
uspto-grants-1984_04
Patent number
US04442126

Reaction notes

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