Hydrogen Bromide → HCID 20463973, compound

HRID 325676Notes

Reaction equation

HRID 325676 reaction equation
[CH2:1]([NH:4][CH:5]1[CH2:14][CH2:13][C:12]2[C:7](=[CH:8][CH:9]=[C:10]([O:16]C)[C:11]=2[NH2:15])[CH2:6]1)[CH2:2][CH3:3].[BrH:18]>>[BrH:18].[CH2:1]([NH:4][CH:5]1[CH2:14][CH2:13][C:12]2[C:7](=[CH:8][CH:9]=[C:10]([OH:16])[C:11]=2[NH2:15])[CH2:6]1)[CH2:2][CH3:3]

Participants

3

Reactant 2

HCID 260Hydrogen BromideHCID 20463960HCID 20463960, compound

Product 1

HCID 20463973HCID 20463973, compound

Procedure

50 ml of 48% hydrobromic acid containing 1.5 g of 2-propylamino-5-amino-6-methoxy-1,2,3,4-tetrahydronaphthalene are heated under reflux for 10 hours. 1.8 g of the dihydrobromide are then collected by concentrating the reaction medium. By following the procedure of Example 2(c), 1.19 g of the monohydrobromide are collected, melting at 280° C.

Workup

  1. temperatureunder reflux for 10 hours
  2. custom1.8 g of the dihydrobromide are then collected
  3. concentrationby concentrating the reaction medium
  4. customare collected

Sources & evidence

ORD record
ord-a966cb406f8a4bb2a3a5fb38b365df00
Source dataset
uspto-grants-1984_04
Patent number
US04442126

Reaction notes

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