反应详情

A solution of 2-hydroxy-3-nitroacetophenone [4.0 g; prepared by the method of Allen et al., J. Chem. Soc., (1949), 821] in ethanol (150 ml) was hydrogenated at 25° C. and 50 p.s.i. for 2.5 hours, using a catalyst of platinum on charcoal. The mixture was filtered and the filtrate was evaporated in vacuo to give a black solid, which was purified by chromatography on a column of silica gel, using diethyl ether as eluant. The fastest moving band (yellow) was collected to give 3-amino-2-hydroxyacetophenone (3.0 g), in the form of a bright yellow solid, m.p. 95°-97° C.

1. customprepared by the method of Allen et al., J
2. customwas hydrogenated at 25° C.
3. filtrationThe mixture was filtered
4. customthe filtrate was evaporated in vacuo
5. customto give a black solid, which
6. customwas purified by chromatography on a column of silica gel
7. customwas collected