反应详情

A solution of freshly prepared 4-methoxybenzyl chloride (45.85 g) in dry dimethylformamide (150 ml) was treated with sodium azide (19.35 g). The stirred mixture was heated at between 100° and 110° C. for 20 hours, and was then cooled and poured into water (1200 ml). The resulting oil was extracted with diethyl ether (2×500 ml) and the combined ethereal extracts were washed with water (2×250 ml), dried over magnesium sulphate, and evaporated to give crude 4-methoxybenzyl azide (45.3 g).

1. temperatureThe stirred mixture was heated at between 100° and 110° C. for 20 hours
2. temperaturewas then cooled
3. extractionThe resulting oil was extracted with diethyl ether (2×500 ml)
4. washthe combined ethereal extracts were washed with water (2×250 ml)
5. dry with materialdried over magnesium sulphate
6. customevaporated