Morpholine, 4-(1-cyclohexen-1-yl)- → 4-Cyclohexylmorpholine

HRID 325760Notes

Reaction equation

HRID 325760 reaction equation
[O:1]1[CH2:6][CH2:5][N:4]([C:7]2[CH2:12][CH2:11][CH2:10][CH2:9][CH:8]=2)[CH2:3][CH2:2]1.P(O)(O)O>>[CH:7]1([N:4]2[CH2:5][CH2:6][O:1][CH2:2][CH2:3]2)[CH2:12][CH2:11][CH2:10][CH2:9][CH2:8]1

Participants

3

Reactant 2

HCID 69589Morpholine, 4-(1-cyclohexen-1-yl)-HCID 107909Phosphorous acid

Product 1

HCID 229384-CyclohexylmorpholineYield 91%

Procedure

1-morpholinocyclohexene (32.3 g; 0.19 mole) and phosphorous acid (15.9 g; 0.19 mole) were heated together with stirring to 100° and maintained for 1 hour. Dilution with water, basification with NaOH and extraction with chloroform gave 29.7 g (91% of N-cyclohexylmorpholine after evaporation of the solvent. ##STR17##

Workup

  1. temperaturemaintained for 1 hour
  2. extractionDilution with water, basification with NaOH and extraction with chloroform

Sources & evidence

ORD record
ord-346fe52e682f44e9923b73f8fd2a4af4
Source dataset
uspto-grants-1984_04
Patent number
US04442286

Reaction notes

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