Hydrochloric Acid → HCID 178527795, compound

HRID 325764Notes

Reaction equation

HRID 325764 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([OH:8])=[C:4]([NH2:9])[CH:3]=1.O(C)[C:11]([S-])=[S:12].[K+].Cl>O>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]2[O:8][C:11]([SH:12])=[N:9][C:4]=2[CH:3]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 72652-Amino-4-chlorophenolHCID 11309586Potassium methylxanthate

Product 1

HCID 178527795HCID 178527795, compoundYield 96.7%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

With the use of the apparatus described in Example 1, 143.6 g (1 mol) of 4-chloro-2-aminophenol and 181.3 g (1.02 mols) of potassium methyl xanthate (90%) in 500 ml of water were refluxed. The reaction was complete within 3 hours. The dark reaction solution was acidified with concentrated hydrochloric acid, the precipitate was suction-filtered and washed neutral with water. After drying in vacuo at 80° C., 179 g (96.7% of th.) of 5-chloro-2-mercaptobenzoxazole having a melting point of 269°-271° C. were obtained.

Workup

  1. temperaturewere refluxed
  2. filtrationthe precipitate was suction-filtered
  3. washwashed neutral with water
  4. customAfter drying in vacuo at 80° C.

Sources & evidence

ORD record
ord-29b46ccecac44aee95e1244be1af4361
Source dataset
uspto-grants-1984_04
Patent number
US04442294

Reaction notes

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