反应详情

A stirred solution of 2.4 g (0.011 mole) of 4-(2-thienyl)-1-indanol and 0.15 g of p-toluenesulfonic acid in 60 mL of toluene was heated under reflux, and the theoretical amount of water by-product was collected in a Dean-Stark trap. The reaction mixture was cooled and washed with two portions of 100 mL each of a 5% aqueous solution of sodium bicarbonate, then with two portions of 50 mL each of water. The organic layer was dried over magnesium sulfate, filtered, and the filtrate concentrated under reduced pressure to give 2.1 g of 7-(2-thienyl)-1H-indene as an oil.

1. temperatureunder reflux
2. customthe theoretical amount of water by-product was collected in a Dean-Stark trap
3. temperatureThe reaction mixture was cooled
4. washwashed with two portions of 100 mL each of a 5% aqueous solution of sodium bicarbonate
5. dry with materialThe organic layer was dried over magnesium sulfate
6. filtrationfiltered
7. concentrationthe filtrate concentrated under reduced pressure