反应详情

A mixture of 35 g of 2-hydroxyphenylsulfonamide, 55.2 g of potassium carbonate, 15.5 ml of propargyl bromide and 1000 ml of ethyl methyl ketone is refluxed for 1.5 hours; it is then cooled, filtered, and concentrated by evaporation. The yield after recrystallisation of the residue from ethyl acetate is 30 g of 2-propargyloxyphenylsulfonamide, m.p. 143°-145° C.

1. temperatureis refluxed for 1.5 hours
2. temperatureit is then cooled
3. filtrationfiltered
4. concentrationconcentrated by evaporation
5. customThe yield
6. customafter recrystallisation of the residue from ethyl acetate