反应详情

To a solution of N-[3-(4-isopropyl-1-piperazinyl)propyl]phthalimide (43.1 g) in ethanol (350 ml) was added 100% hydrazine hydrate (11.2 g). The resulting mixture was refluxed with stirring for 3 hours. The reaction mixture was cooled and then filtered. The filter cake was washed with ethanol. The filtrate and washing were combined and concentrated under reduced pressure. The residual oil was subjected to column chromatography (aluminum oxide), eluting with a mixture of chloroform and methanol (20:1). The fractions containing the object compound were collected and then evaporated under reduced pressure. The residual oil was distilled under reduced pressure to give 3-(4-isopropyl-1-piperazinyl)propylamine (15.0 g), (bp 45 mmHg/150° C.).

1. temperatureThe resulting mixture was refluxed
2. temperatureThe reaction mixture was cooled
3. filtrationfiltered
4. washThe filter cake was washed with ethanol
5. washThe filtrate and washing
6. concentrationconcentrated under reduced pressure
7. washeluting with a mixture of chloroform and methanol (20:1)
8. additionThe fractions containing the object compound
9. customwere collected
10. customevaporated under reduced pressure
11. distillationThe residual oil was distilled under reduced pressure