反应详情

To a solution of N-[3-(4-phenyl-1-piperazinyl)propyl]phthalimide (18.3 g) in ethanol (300 ml) was added 100% hydrazine hydrate (5.3 g). The resulting mixture was refluxed with stirring for 2 hours. The reaction mixture was evaporated under reduced pressure. After the addition of dil. aqueous solution of sodium hydroxide to the residue, the mixture was extracted with chloroform. The extract was washed with water, dried over magnesium sulfate and then evaporated under reduced pressure to give 3-(4-phenyl-1-piperazinyl)propylamine (11.2 g).

1. temperatureThe resulting mixture was refluxed
2. customThe reaction mixture was evaporated under reduced pressure
3. additionAfter the addition of dil. aqueous solution of sodium hydroxide to the residue
4. extractionthe mixture was extracted with chloroform
5. washThe extract was washed with water
6. dry with materialdried over magnesium sulfate
7. customevaporated under reduced pressure