3,4'-Dichloropropiophenone → 3-[4-(5-Methoxy-1-naphthalenyloxy)-1-piperidyl]-1-(4-chlorophenyl)-1-propanone hydrochloride

HRID 325963Notes

Reaction equation

HRID 325963 reaction equation
Cl.[CH3:2][O:3][C:4]1[CH:13]=[CH:12][CH:11]=[C:10]2[C:5]=1[CH:6]=[CH:7][CH:8]=[C:9]2[O:14][CH:15]1[CH2:20][CH2:19][NH:18][CH2:17][CH2:16]1.Cl.C1C2C(=CC=CC=2)C=CC=1OC1CCNCC1.[Cl:39][CH2:40][CH2:41][C:42]([C:44]1[CH:49]=[CH:48][C:47]([Cl:50])=[CH:46][CH:45]=1)=[O:43].ClCCCC(C1C=CC=CC=1)=O>>[ClH:39].[CH3:2][O:3][C:4]1[CH:13]=[CH:12][CH:11]=[C:10]2[C:5]=1[CH:6]=[CH:7][CH:8]=[C:9]2[O:14][CH:15]1[CH2:20][CH2:19][N:18]([CH2:40][CH2:41][C:42]([C:44]2[CH:45]=[CH:46][C:47]([Cl:50])=[CH:48][CH:49]=2)=[O:43])[CH2:17][CH2:16]1

Participants

5

Reactant 4

HCID 775503,4'-DichloropropiophenoneHCID 2535334-ChlorobutyrophenoneHCID 184233502-Naphthyl 4-Piperidinyl Ether HydrochlorideHCID 204632304-(5-Methoxy-1-naphthalenyloxy)piperidine hydrochloride

Product 1

HCID 204632253-[4-(5-Methoxy-1-naphthalenyloxy)-1-piperidyl]-1-(4-chlorophenyl)-1-propanone hydrochloride

Procedure

When in the procedure of Example 13, 4-(5-methoxy-1-naphthalenyloxy)piperidine hydrochloride is substituted for 4-(2-naphthalenyloxy)piperidine hydrochloride and 3-chloro-1-(4-chlorophenyl)-1-propanone substituted for 4-chloro-1-phenyl-1-butanone, 3-[4-(5-methoxy-1-naphthalenyloxy)-1-piperidyl]-1-(4-chlorophenyl)-1-propanone hydrochloride is produced.

Sources & evidence

ORD record
ord-14c4f3bdc3a64a6bbb4be51aaf7e57d7
Source dataset
uspto-grants-1984_04
Patent number
US04443462

Reaction notes

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