HRID325965

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID19750

4-Chloro-4'-fluorobutyrophenone

C10H10ClFO

HCID10613105

1-Hexanone, 6-bromo-1-(4-methoxyphenyl)-

C13H17BrO2

HCID20463209

未命名化合物

HCID20463219

未命名化合物

PRODUCTS

生成物

结构：COc1ccc(C(=O)CCCCCN2CCC(Oc3cc(C(F)(F)F)c4ccccc4c3)CC2)cc1

HCID20463203

未命名化合物

PROCEDURE

实验过程

When in the procedure of Example 18, 4-(4-trifluoromethyl-2-naphthalenyloxy)piperidine is substituted for 4-(1-methyl-2-naphthalenyloxy)piperidine and 6-bromo-1-(4-methoxyphenyl)-1-hexanone substituted for 4-chloro-1-(4-fluorophenyl)-1-butanone, 6-[4-(4-trifluoromethyl-2-naphthalenyloxy)-1-piperidyl]-1-(4-methoxyphenyl)-1-hexanone is obtained.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-bf67f7edf97d4b138991dcc419cd55a3
来源数据集: uspto-grants-1984_04
DOI: 10.6084/m9.figshare.5104873.v1
专利: US04443462
来源说明: uspto-grants-1984_04

反应 SMILES

[F:1][C:2]([F:21])([F:20])[C:3]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[CH:6]=[C:5]([O:13][CH:14]2[CH2:19][CH2:18][NH:17][CH2:16][CH2:15]2)[CH:4]=1.CC1C2C(=CC=CC=2)C=CC=1OC1CCNCC1.Br[CH2:41][CH2:42][CH2:43][CH2:44][CH2:45][C:46]([C:48]1[CH:53]=[CH:52][C:51]([O:54][CH3:55])=[CH:50][CH:49]=1)=[O:47].ClCCCC(C1C=CC(F)=CC=1)=O>>[F:21][C:2]([F:1])([F:20])[C:3]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[CH:6]=[C:5]([O:13][CH:14]2[CH2:19][CH2:18][N:17]([CH2:41][CH2:42][CH2:43][CH2:44][CH2:45][C:46]([C:48]3[CH:53]=[CH:52][C:51]([O:54][CH3:55])=[CH:50][CH:49]=3)=[O:47])[CH2:16][CH2:15]2)[CH:4]=1