HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-(4-Fluorobenzoyl)propyl chloride → 6-[4-(4-Trifluoromethyl-2-naphthalenyloxy)-1-piperidyl]-1-(4-methoxyphenyl)-1-hexanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-(4-Fluorobenzoyl)propyl chloride | HCID 19750 | — |
| Reactant | 1-Hexanone, 6-bromo-1-(4-methoxyphenyl)- | HCID 10613105 | — |
| Reactant | 4-(1-Methyl-2-naphthalenyloxy)piperidine | HCID 20463209 | — |
| Reactant | 4-(4-Trifluoromethyl-2-naphthalenyloxy)piperidine | HCID 20463219 | — |
| Product | 6-[4-(4-Trifluoromethyl-2-naphthalenyloxy)-1-piperidyl]-1-(4-methoxyphenyl)-1-hexanone | HCID 20463203 | — |
Reaction Steps
When in the procedure of Example 18, 4-(4-trifluoromethyl-2-naphthalenyloxy)piperidine is substituted for 4-(1-methyl-2-naphthalenyloxy)piperidine and 6-bromo-1-(4-methoxyphenyl)-1-hexanone substituted for 4-chloro-1-(4-fluorophenyl)-1-butanone, 6-[4-(4-trifluoromethyl-2-naphthalenyloxy)-1-piperidyl]-1-(4-methoxyphenyl)-1-hexanone is obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04443462 |
| Source dataset | uspto-grants-1984_04 |
| ORD ID | ord-bf67f7edf97d4b138991dcc419cd55a3 |
| Source note | uspto-grants-1984_04 |