反应详情

Furo[3,2-d]pyrimidin-4(3H)-one (Intermediate 83) (1.49 g) and phosphorus oxychloride (15 mL) were heated to 120° C. for 45 minutes, cooled to ambient temperature, and evaporated under high vacuum. The residue was added to 50% saturated sodium carbonate (100 mL) and extracted into DCM (3×100 mL). The combined organics were dried and the solvent removed to afford the title compound as an orange solid (1.32 g, 78%);

1. customevaporated under high vacuum
2. additionThe residue was added to 50% saturated sodium carbonate (100 mL)
3. extractionextracted into DCM (3×100 mL)
4. customThe combined organics were dried
5. customthe solvent removed