反应详情

4.2 g of 2-(2-aminopropyl)-4-phenyl-1(2H)-isoquinolone, 2.7 g of ethyl chlorocarbonate, 4.1 g of potassium carbonate and 60 ml of ethanol were mixed and stirred at room temperature for 3 hours. The solvent was then distilled off, and the residue was extracted with dichloromethane. The crystals obtained by distilling off the solvent were recrystallized from ethanol to obtain 3 g (57% yield) of 2-(2-ethoxycarbonylaminopropyl)-4-phenyl-1(2H)-isoquinolone having a melting point of 182° C. as colorless prisms.

1. distillationThe solvent was then distilled off
2. extractionthe residue was extracted with dichloromethane
3. customThe crystals obtained
4. distillationby distilling off the solvent
5. customwere recrystallized from ethanol