HCID 20461931, compound → HCID 20461932, compound

HRID 326031Notes

Reaction equation

HRID 326031 reaction equation
[F:1][CH:2]([F:17])[O:3][C:4]1[CH:9]=[CH:8][C:7]([O:10][CH:11]([F:13])[F:12])=[CH:6][C:5]=1[N+:14]([O-])=O.[H][H]>[Ni].O1CCOCC1>[F:1][CH:2]([F:17])[O:3][C:4]1[CH:9]=[CH:8][C:7]([O:10][CH:11]([F:13])[F:12])=[CH:6][C:5]=1[NH2:14]

Participants

5

Reactant 2

HCID 20461931HCID 20461931, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 20461932HCID 20461932, compoundYield 98.9%

Reagents, catalysts & solvents 2

HCID 935NickelCatalystHCID 312751,4-DioxaneSolvent

Procedure

A mixture of 12.6 g of 2.5-bis(difluoromethoxy)nitrobenzene, 1.3 g of Raney-nickel catalyst and 130 ml of dioxane is agitated in a hydrogen atmosphere for 15 hours at a temperature of 20°-25° C. The hydrogen consumption is 3.34 liters. After removal of the catalyst the mixture is evaporated to dryness, yielding 11.0 g of crude 2.5-bis(difluoromethoxy) aniline in form of a yellow-brown oil.

Workup

  1. customThe hydrogen consumption
  2. customAfter removal of the catalyst the mixture
  3. customis evaporated to dryness

Sources & evidence

ORD record
ord-6ce05736c2b34add84b94af62ae7758a
Source dataset
uspto-grants-1984_04
Patent number
US04444583

Reaction notes

Loading…