反应详情

Following example 10, 16.32 g of 50% sodium hydride-mineral oil dispersion (8.16 g NaH, 0.34 M), 40 g (0.283 M) of azacyclononan-2-one and 43 g (0.311 M) of 1-bromobutane was refluxed for 22 hours. The reaction mixture was diluted with benzene-tolune and was extracted with water. The organic phase was separated, dried and concentrated to a yellow oil. Distillation afforded 41.4 g (74%) of product; b.p. 166°-170°/0.2 mm.

1. temperaturewas refluxed for 22 hours
2. extractionwas extracted with water
3. customThe organic phase was separated
4. customdried
5. concentrationconcentrated to a yellow oil
6. distillationDistillation