反应详情

Potassium cyanide (11.18 g) and dibenzo-18-crown-6 (1.0 g) are added to a solution of 4-(3-chloropropyl)-pyridine (6.68 g) prepared from 4-(3-hydroxypropyl)pyridine, in 300 ml of dry acetonitrile under nitrogen. The mixture is refluxed for 24 hours, the solvent evaporated and the residue partitioned between methylene chloride and water. The aqueous phase is further extracted with methylene chloride (3×100 ml) and the combined extracts are dried over sodium sulfate, decolorized with charcoal and evaporated to yield 4-(3-cyanopropyl)pyridine as a colorless oil.

1. temperatureThe mixture is refluxed for 24 hours
2. customthe solvent evaporated
3. customthe residue partitioned between methylene chloride and water
4. extractionThe aqueous phase is further extracted with methylene chloride (3×100 ml)
5. dry with materialthe combined extracts are dried over sodium sulfate
6. customevaporated