反应详情

Pyridinium dichromate (0.94 g) is added as a solid to a solution of 5-(6-hydroxyhexyl)-imidazo[1,5-a]pyridine (123 mg) in 10 ml of N,N-dimethylformamide at 25° under nitrogen. The solution is stirred for 6 hours, poured into 150 ml of water and extracted with methylene chloride (5×20 ml). The organic extracts are washed with 1 N sodium hydroxide. Acidification of the aqueous phase to pH=6, extraction with methylene chloride and drying over sodium sulfate/magnesium sulfate yields 5-(5-carboxypentyl)-imidazo[1,5-a]pyridine of Example 2 melting at 145°-146°.

1. extractionextracted with methylene chloride (5×20 ml)
2. washThe organic extracts are washed with 1 N sodium hydroxide
3. extractionAcidification of the aqueous phase to pH=6, extraction with methylene chloride
4. dry with materialdrying over sodium sulfate/magnesium sulfate