1-Bromo-3-chloropropane → HCID 67852080, compound

HRID 326245Notes

Reaction equation

HRID 326245 reaction equation
Cl[CH2:2]CCBr.[CH3:6][N:7]1[C:11]2[CH:12]=[CH:13][C:14]([CH2:16][CH2:17][NH:18][CH3:19])=[CH:15][C:10]=2[S:9](=[O:20])[CH2:8]1.C[N:22]1[C:26]2C=CC(CCNCCC)=C[C:25]=2S(=O)C1>>[CH3:6][N:7]1[C:11]2[CH:12]=[CH:13][C:14]([CH2:16][CH2:17][N:18]([CH3:2])[CH2:19][CH2:25][CH2:26][NH2:22])=[CH:15][C:10]=2[S:9](=[O:20])[CH2:8]1

Participants

4

Reactant 3

HCID 80061-Bromo-3-chloropropaneHCID 67713193HCID 67713193, compoundHCID 67852074HCID 67852074, compound

Product 1

HCID 67852080HCID 67852080, compound

Procedure

Using the procedure described in Example 19, but replacing 1-chloro-2-bromoethane by 1-chloro-3-bromopropane and 3-methyl-6-[2-(N-methylamino)ethyl]benzothiazolinone by 3-methyl-6- [2-(N-n-propylamino)ethyl]-benzothiazolinone, 3-methyl-6-{2-[N-methyl-N-(3-aminopropyl)amino]ethyl} benzothiazolinone is obtained, which product is treated as in Example 20 with tosyl chloride to yield the product of the title.

Sources & evidence

ORD record
ord-9c4b85eed85c47afbf006aaf3361915b
Source dataset
uspto-grants-1993_12
Patent number
US05268381

Reaction notes

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