1H-1,2,4-Triazole → HCID 67725164, compound

HRID 326266Notes

Reaction equation

HRID 326266 reaction equation
Cl[CH:2]([C:13]1[CH:18]=[CH:17][C:16]([Cl:19])=[CH:15][CH:14]=1)[C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[N:9]=[CH:8][CH:7]=[CH:6]2.[NH:20]1[CH:24]=[N:23][CH:22]=[N:21]1.C(=O)([O-])[O-:26].[K+].[K+]>C(#N)C>[OH2:26].[Cl:19][C:16]1[CH:17]=[CH:18][C:13]([CH:2]([N:23]2[CH:22]=[N:21][N:20]=[CH:24]2)[C:3]2[CH:4]=[C:5]3[C:10](=[CH:11][CH:12]=2)[N:9]=[CH:8][CH:7]=[CH:6]3)=[CH:14][CH:15]=1.[Cl:19][C:16]1[CH:17]=[CH:18][C:13]([CH:2]([C:3]2[CH:4]=[C:5]3[C:10](=[CH:11][CH:12]=2)[N:9]=[CH:8][CH:7]=[CH:6]3)[N:23]2[CH:22]=[N:21][N:20]=[CH:24]2)=[CH:14][CH:15]=1

Participants

5

Reactant 3

HCID 92571H-1,2,4-TriazoleHCID 11430Potassium CarbonateHCID 19967109HCID 19967109, compound

Product 1

HCID 67725164HCID 67725164, compoundYield 49.2%

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

A mixture of 5.34 parts of 6-[chloro(4-chlorophenyl)methyl]quinoline, 6.4 parts of 1H-1,2,4-triazole, 1:26 parts of potassium carbonate and 79 parts of acetonitrile was stirred for 8 hours at reflux temperature. After evaporation to dry, the residue was taken up in water and was further purified according to similar procedures as described in example 12, yielding 3 parts (49.2%) of 6-[(4-chlorophenyl)(4H-1,2,4-triazol-4-yl)-methyl]quinoline hemihydrate; mp. 87.8° C. (compound 45).

Workup

  1. temperatureat reflux temperature
  2. customAfter evaporation
  3. customto dry
  4. customwas further purified

Sources & evidence

ORD record
ord-c21fb4e69659494185bbb19f812a587e
Source dataset
uspto-grants-1993_12
Patent number
US05268380

Reaction notes

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