反应详情

温度

60 °C

A solution of 2,4,5-trimethyl-3-furancarbonyl chloride (7.8 g, 0.045 mole) in toluene (25 ml) was added to 1-methylethyl 5-amino-2-chlorobenzoate (10.6 g, 0.050 mole) and triethylamine (6 g) in toluene (25 ml). The mixture was warmed to 60° C. for about 1 hour, then washed in sequence with dilute hydrochloric acid, water, aqueous 5% sodium bicarbonate and water. The solution was dried with magnesium sulfate, filtered and evaporated. The residue was crystallized from toluene/petroleum ether to give 6.7 g of a pale yellow solid, m.p. 83°-85° C.

1. washwashed in sequence with dilute hydrochloric acid, water, aqueous 5% sodium bicarbonate and water
2. dry with materialThe solution was dried with magnesium sulfate
3. filtrationfiltered
4. customevaporated
5. customThe residue was crystallized from toluene/petroleum ether