HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzoyl chloride → Isopropyl 5-benzamido-2-chloro-4-fluoro-benzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzoyl chloride | HCID 7412 | — |
| Reactant | Propan-2-yl 5-amino-2-chloro-4-fluorobenzoate | HCID 13519894 | — |
| Solvent | Methyl Ethyl Ketone | HCID 6569 | — |
| Product | Isopropyl 5-benzamido-2-chloro-4-fluoro-benzoate | HCID 507314 | 90% |
Reaction Steps
A solution of benzoyl chloride (2.94 g, 0.021 mole) and 1-methylethyl 5-amino-2-chloro-4-fluorobenzoate (4.62 g, 0.020 mole) in methyl ethyl ketone (50 ml) was stirred at room temperature for 3 days. Evaporation of the solvent and crystallization of the solid residue from ethyl ether gave colorless needles, m.p. 117°-119° C. (6 g, 90% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05268389 |
| Source dataset | uspto-grants-1993_12 |
| ORD ID | ord-7b73076e500c4e2e99da51880a681630 |
| Source note | uspto-grants-1993_12 |