HCID 14629903, compound → HCID 14629908, compound

HRID 326388Notes

Reaction equation

HRID 326388 reaction equation
C(OC([NH:11][C@H:12]([C@@H:20]([OH:29])[C:21]([F:28])([F:27])[C@H:22]([OH:26])[CH:23]([CH3:25])[CH3:24])[CH2:13][CH:14]1[CH2:19][CH2:18][CH2:17][CH2:16][CH2:15]1)=O)C1C=CC=CC=1>CO.[Pd]>[NH2:11][C@H:12]([C@@H:20]([OH:29])[C:21]([F:27])([F:28])[C@H:22]([OH:26])[CH:23]([CH3:25])[CH3:24])[CH2:13][CH:14]1[CH2:19][CH2:18][CH2:17][CH2:16][CH2:15]1

Participants

4

Reactant 1

HCID 14629903HCID 14629903, compound

Product 1

HCID 14629908HCID 14629908, compoundYield 99.4%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

A solution of 700 mg of the product from Example 177 in 10 ml of methanol was stirred vigorously under a hydrogen atmosphere using 10% Pd/C as catalyst. After 30 min, the catalyst was filtered off and the solution concentrated to give 470 mg the desired product. Mass spectrum: M+ =279.

Workup

  1. filtrationthe catalyst was filtered off
  2. concentrationthe solution concentrated

Sources & evidence

ORD record
ord-a6181ea709bb466aaddded53449fe280
Source dataset
uspto-grants-1993_12
Patent number
US05268374

Reaction notes

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