HRID326456

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID9740

Cyanoacetic acid

C3H3NO2

结构：CCCCc1nc2c(n1Cc1ccc(-c3ccccc3-c3nnn[nH]3)cc1)CNC(C(=O)OC)C2.Cl

HCID178441551

未命名化合物

PRODUCTS

生成物

结构：CCCCc1nc2c(n1Cc1ccc(-c3ccccc3-c3nnn[nH]3)cc1)CN(C(=O)CC#N)C(C(=O)OC)C2

HCID178441552

未命名化合物

PROCEDURE

实验过程

Methyl 2-n-butyl-3-{2'-(1H-tetrazol-5-yl)-biphenyl-4-yl}methyl-4,5,6,7-tetrahydroimidazo[4,5-c]-pyridine-6-carboxylate hydrochloride and cyanoacetic acid are treated in the same manner as in Example 8-(1) to give methyl 2-n-butyl-5-cyanoacetyl-3-{2'-(1H-tetrazol-5-yl)-biphenyl-4-yl}methyl-4,5,6,7-tetrahydroimidazo[4,5-c]-pyridine-6-carboxylate.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-8f2baa26b3a94914b70108ccadff96fd
来源数据集: uspto-grants-1993_12
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05268377
来源说明: uspto-grants-1993_12

反应 SMILES

Cl.[CH2:2]([C:6]1[N:18]([CH2:19][C:20]2[CH:25]=[CH:24][C:23]([C:26]3[CH:31]=[CH:30][CH:29]=[CH:28][C:27]=3[C:32]3[NH:36][N:35]=[N:34][N:33]=3)=[CH:22][CH:21]=2)[C:9]2[CH2:10][NH:11][CH:12]([C:14]([O:16][CH3:17])=[O:15])[CH2:13][C:8]=2[N:7]=1)[CH2:3][CH2:4][CH3:5].[C:37]([CH2:39][C:40](O)=[O:41])#[N:38]>>[CH2:2]([C:6]1[N:18]([CH2:19][C:20]2[CH:25]=[CH:24][C:23]([C:26]3[CH:31]=[CH:30][CH:29]=[CH:28][C:27]=3[C:32]3[NH:36][N:35]=[N:34][N:33]=3)=[CH:22][CH:21]=2)[C:9]2[CH2:10][N:11]([C:40](=[O:41])[CH2:39][C:37]#[N:38])[CH:12]([C:14]([O:16][CH3:17])=[O:15])[CH2:13][C:8]=2[N:7]=1)[CH2:3][CH2:4][CH3:5]