反应详情

A mixture of 40.6 mg (0.15 mmol) 2-Morpholin-4-yl-5-nitro-benzoyl chloride, 39.9 mg (0.18 mmol) 3-Chloro-4-piperazin-1-yl-benzonitrile (WO9625414) and 62.5 ul (0.45 mmol) NEt3 in 1 ml DCM was stirred at room temperature for 16 h. After evaporation of the volatiles the residue was taken up in 1 ml CH3CN/DMF/HCOOH 3/5/2 and subjected to preparative HPLC purification on reversed phase eluting with an acetonitrile/water gradient to yield after evaporation of the product fractions 4.9 mg (8%) of the title compound. MS (m/e): 456.2 (MH+, 100%)

1. customAfter evaporation of the volatiles the residue
2. customsubjected to preparative HPLC purification on reversed phase
3. washeluting with an acetonitrile/water gradient
4. customto yield
5. customafter evaporation of the product fractions 4.9 mg (8%) of the title compound