反应详情

Treatment of methyl 5,6,7-trichloro-4-oxo-1,4-dihydroquinoline-2-carboxylate (3 g) with sodium hydroxide (1.57 g) as described in Example 1c, gave 5,6,7-trichloro-4-oxo-1,4-dihydroquinoline-2-carboxylic acid (2.15 g). m.p. 290° C. (dec), δ (360 MHz, NAOD) 6.69 (1H, s, 3-H) and 7.66 (1H, s, 8-H) (Found: C, 40.90; H, 1.15; N, 4.78%, C10H4NO3Cl3 requires C, 41.06; H, 1.38; N, 4.79%).