Sodium Hydroxide → HCID 14842745, compound

HRID 326634Notes

Reaction equation

[CH3:1][S:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[NH:9][C:8]([C:13]([O:15]C)=[O:14])=[CH:7][C:6]2=[O:17].[OH-].[Na+]>>[CH3:1][S:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[NH:9][C:8]([C:13]([OH:15])=[O:14])=[CH:7][C:6]2=[O:17]

Participants

Reactant 2

HCID 14798Sodium Hydroxide

HCID 619331HCID 619331, compound

Product 1

HCID 14842745HCID 14842745, compoundYield 84.8%

Procedure

Treatment of methyl 6-methylthio-4-oxo-1,4-dihydroquinoline-2-carboxylate (2.0 g) with sodium hydroxide (1.29 g), as described in Example 1c, gave 6-methylthio-4-oxo-1,4-dihydroquinoline-2-carboxylic acid (1.6 g), m.p. 256°-257° C. δ (360 MHz, DMSO-d6) 2.55 (3H, s, CH3S), 6.65 (1H, s, 3-H), 7.62 (1H, dd, 7-H), 7.83 (1H, d, 5-H) and 7.90 (1H, d, 8-H). (Found: C, 54.08; H, 4.19; N, 5.72% C11H9NO3S.0.5H2O requires C, 54.09; H. 4.13; N. 5.72%)

Sources & evidence

ORD record: ord-48c31faa3aab448692aa4493986830f3
Source dataset: uspto-grants-1993_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05270309

Reaction notes

Loading…