Sodium Hydroxide → HCID 14842745, compound

Participants

Reaction Steps

Treatment of methyl 6-methylthio-4-oxo-1,4-dihydroquinoline-2-carboxylate (2.0 g) with sodium hydroxide (1.29 g), as described in Example 1c, gave 6-methylthio-4-oxo-1,4-dihydroquinoline-2-carboxylic acid (1.6 g), m.p. 256°-257° C. δ (360 MHz, DMSO-d6) 2.55 (3H, s, CH3S), 6.65 (1H, s, 3-H), 7.62 (1H, dd, 7-H), 7.83 (1H, d, 5-H) and 7.90 (1H, d, 8-H). (Found: C, 54.08; H, 4.19; N, 5.72% C11H9NO3S.0.5H2O requires C, 54.09; H. 4.13; N. 5.72%)

Provenance & Evidence