反应详情

A mixture of 1 g (4 mmol) 2-Chloro-5-sulfino-benzoic acid and 0.62 g (20 mmol) Methylamine in 10 ml dioxane was stirred for 3 h at room temperature. After evaporation of the volatiles 15 ml 5N HCl was added and the mixture was extracted 3× with ethylacetate. The solvent was removed under vacuum to yield 0.724 g (72%) of the title compound as amorphous white solid. MS (m/e): 248.1 (MH−, 100%).

1. customAfter evaporation of the volatiles 15 ml 5N HCl
2. additionwas added
3. extractionthe mixture was extracted 3× with ethylacetate
4. customThe solvent was removed under vacuum