Formamidine acetate → HCID 19735286, compound

HRID 326703Notes

Reaction equation

HRID 326703 reaction equation
C(O)(=O)C.[CH:5]([NH2:7])=[NH:6].CC[O-].[Na+].[F:12][C:13]([F:33])([F:32])[C:14]1[CH:31]=[CH:30][CH:29]=[CH:28][C:15]=1[CH2:16][CH:17]([C:23](OCC)=[O:24])[C:18](OCC)=[O:19]>C(O)C>[F:12][C:13]([F:32])([F:33])[C:14]1[CH:31]=[CH:30][CH:29]=[CH:28][C:15]=1[CH2:16][CH:17]1[C:23](=[O:24])[NH:7][CH:5]=[N:6][C:18]1=[O:19]

Participants

5

Reactant 3

HCID 160693Formamidine acetateHCID 2723922Sodium ethoxideHCID 537090431,3-Diethyl 2-[[2-(trifluoromethyl)phenyl]methyl]propanedioate

Product 1

HCID 19735286HCID 19735286, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent2×

Procedure

0.63 g of formamidine acetate in 40 ml of absolute ethyl alcohol was treated with 1.2 g of sodium ethylate at room temperature, stirred at room temperature for 30 minutes and then treated dropwise at room temperature with a solution of 1.6 g of diethyl [o-(trifluoromethyl)benzyl]malonate in 8 ml of absolute ethyl alcohol. After stirring at 50° C. for 4 hours, the reaction mixture was worked-up and yielded 5-[o-(trifluoro-methyl)benzyl]-4,6(1H,5H)pyrimidinedione, melting point >290° C.

Workup

  1. stirringAfter stirring at 50° C. for 4 hours

Sources & evidence

ORD record
ord-447e051c1f574ccc9b08459938f456dc
Source dataset
uspto-grants-1993_12
Patent number
US05270313

Reaction notes

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