HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Pyrrolidin-1-ylmethyl-piperidine → 1-(4,5-Dichloro-3-oxoindan-1-carbonyl)-2-(pyrrolidin-1-ylmethyl)piperidine hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Pyrrolidin-1-ylmethyl-piperidine | HCID 2760541 | — |
| Reactant | 4,5-Dichloro-3-oxoindan-1-carbonyl chloride | HCID 18914966 | — |
| Solvent | Triethylamine | HCID 8471 | — |
| Product | 1-(4,5-Dichloro-3-oxoindan-1-carbonyl)-2-(pyrrolidin-1-ylmethyl)piperidine hydrochloride | HCID 18914980 | 57.1% |
Reaction Steps
From 1.18 g of 2-(pyrrolidin-1-ylmethyl)piperidine, 2.03 g of 4,5-dichloro-3-oxoindan-1-carbonyl chloride and 1.47 ml of triethylamine. 0.95 g of the title compound was obtained, melting at 148°-150° C. (dec) using a procedure similar to that in Example 2.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05270327 |
| Source dataset | uspto-grants-1993_12 |
| ORD ID | ord-da4198d70a64449db01d723526660aec |
| Source note | uspto-grants-1993_12 |