2-Pyrrolidin-1-ylmethyl-piperidine → 1-(4,5-Dichloro-3-oxoindan-1-carbonyl)-2-(pyrrolidin-1-ylmethyl)piperidine hydrochloride

HRID 326729Notes

Reaction equation

HRID 326729 reaction equation
[N:1]1([CH2:6][CH:7]2[CH2:12][CH2:11][CH2:10][CH2:9][NH:8]2)[CH2:5][CH2:4][CH2:3][CH2:2]1.[Cl:13][C:14]1[C:22]([Cl:23])=[CH:21][CH:20]=[C:19]2[C:15]=1[C:16](=[O:27])[CH2:17][CH:18]2[C:24](Cl)=[O:25]>C(N(CC)CC)C>[ClH:13].[Cl:13][C:14]1[C:22]([Cl:23])=[CH:21][CH:20]=[C:19]2[C:15]=1[C:16](=[O:27])[CH2:17][CH:18]2[C:24]([N:8]1[CH2:9][CH2:10][CH2:11][CH2:12][CH:7]1[CH2:6][N:1]1[CH2:5][CH2:4][CH2:3][CH2:2]1)=[O:25]

Participants

4

Reactant 2

HCID 27605412-Pyrrolidin-1-ylmethyl-piperidineHCID 189149664,5-Dichloro-3-oxoindan-1-carbonyl chloride

Product 1

HCID 189149801-(4,5-Dichloro-3-oxoindan-1-carbonyl)-2-(pyrrolidin-1-ylmethyl)piperidine hydrochlorideYield 57.1%

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Procedure

From 1.18 g of 2-(pyrrolidin-1-ylmethyl)piperidine, 2.03 g of 4,5-dichloro-3-oxoindan-1-carbonyl chloride and 1.47 ml of triethylamine. 0.95 g of the title compound was obtained, melting at 148°-150° C. (dec) using a procedure similar to that in Example 2.

Sources & evidence

ORD record
ord-da4198d70a64449db01d723526660aec
Source dataset
uspto-grants-1993_12
Patent number
US05270327

Reaction notes

Loading…