Sodium Hydroxide → 1-(5.6-Dichloro-3-oxoindan-1-carbonyl)-2-(piperidinomethyl)piperidine hydrochloride
Reaction equation
Cl.Cl.[N:3]1([CH2:9][CH:10]2[CH2:15][CH2:14][CH2:13][CH2:12][NH:11]2)[CH2:8][CH2:7][CH2:6][CH2:5][CH2:4]1.[Cl:16][C:17]1[CH:18]=[C:19]2[C:23](=[CH:24][C:25]=1[Cl:26])[CH:22]([C:27](Cl)=[O:28])[CH2:21][C:20]2=[O:30].[OH-].[Na+]>>[ClH:16].[Cl:16][C:17]1[CH:18]=[C:19]2[C:23](=[CH:24][C:25]=1[Cl:26])[CH:22]([C:27]([N:11]1[CH2:12][CH2:13][CH2:14][CH2:15][CH:10]1[CH2:9][N:3]1[CH2:8][CH2:7][CH2:6][CH2:5][CH2:4]1)=[O:28])[CH2:21][C:20]2=[O:30]Participants
4
Procedure
From 1.5 g of 2-(piperidinomethyl)piperidine dihydrochloride, 2.5 g of 5,6-dichloro-3-oxoindan-1-carbonyl chloride and 45 ml of 1N aqueous sodium hydroxide solution. 1.1 g of the title compound was obtained, melting at 240°-245° C. (dec), using a procedure similar to that in Example 1.
Sources & evidence
- ORD record
- ord-787fd9d25b634d2898a2fbd5c2741d85
- Source dataset
- uspto-grants-1993_12
- Patent number
- US05270327
Reaction notes
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