HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → 1-(1,2,3,4-Tetrahydro-4-oxo-1-naphthoyl)-2-(pyrrolidin1-ylmethyl)piperidine hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 2-(1-Pyrrolidinylmethyl)piperidine dihydrochloride | HCID 18915120 | — |
| Reactant | 1,2,3,4-Tetrahydro-4-oxo-1-naphthoyl chloride | HCID 18915136 | — |
| Product | 1-(1,2,3,4-Tetrahydro-4-oxo-1-naphthoyl)-2-(pyrrolidin1-ylmethyl)piperidine hydrochloride | HCID 18914971 | 76.7% |
Reaction Steps
From 3.48 g of 2-(pyrrolidin-1-ylmethyl)piperidine dihydrochloride, 4.44 g of 1,2,3,4-tetrahydro-4-oxo-1-naphthoyl chloride and 63.9 ml of 1N aqueous sodium hydroxide solution. 4.17 g of the title compound was obtained, melting at 239°-242° C. (dec). using a procedure similar to that in Example 1.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05270327 |
| Source dataset | uspto-grants-1993_12 |
| ORD ID | ord-3a48b6788680461e9da54efb9ee6e79c |
| Source note | uspto-grants-1993_12 |