HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Thiopheneacetyl chloride → 3-(Pyrrolidin-1-ylmethyl)-4-(2-thienylacetyl)morpholine hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Thiopheneacetyl chloride | HCID 162362 | — |
| Reactant | 3-(Pyrrolidin-1-ylmethyl)morpholine | HCID 18915061 | — |
| Solvent | Triethylamine | HCID 8471 | — |
| Product | 3-(Pyrrolidin-1-ylmethyl)-4-(2-thienylacetyl)morpholine hydrochloride | HCID 18915185 | 76.6% |
Reaction Steps
The procedure described in Example 17 was repeated, but using 0.88 g of 3-(pyrrolidin-1-ylmethyl)morpholine, 2.0 ml of triethylamine and 0.45 g of 2-thienylacetyl chloride, to afford 0.71 g of the title compound melting at 215° C. (dec.).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05270327 |
| Source dataset | uspto-grants-1993_12 |
| ORD ID | ord-e092e6f993364bb2b396931b6ebf815a |
| Source note | uspto-grants-1993_12 |