2-Thiopheneacetyl chloride → 3-(Pyrrolidin-1-ylmethyl)-4-(2-thienylacetyl)morpholine hydrochloride

HRID 326735Notes

Reaction equation

HRID 326735 reaction equation
[N:1]1([CH2:6][CH:7]2[CH2:12][O:11][CH2:10][CH2:9][NH:8]2)[CH2:5][CH2:4][CH2:3][CH2:2]1.[S:13]1[CH:17]=[CH:16][CH:15]=[C:14]1[CH2:18][C:19]([Cl:21])=[O:20]>C(N(CC)CC)C>[ClH:21].[N:1]1([CH2:6][CH:7]2[CH2:12][O:11][CH2:10][CH2:9][N:8]2[C:19](=[O:20])[CH2:18][C:14]2[S:13][CH:17]=[CH:16][CH:15]=2)[CH2:2][CH2:3][CH2:4][CH2:5]1

Participants

4

Reactant 2

HCID 1623622-Thiopheneacetyl chlorideHCID 189150613-(Pyrrolidin-1-ylmethyl)morpholine

Product 1

HCID 189151853-(Pyrrolidin-1-ylmethyl)-4-(2-thienylacetyl)morpholine hydrochlorideYield 76.6%

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Procedure

The procedure described in Example 17 was repeated, but using 0.88 g of 3-(pyrrolidin-1-ylmethyl)morpholine, 2.0 ml of triethylamine and 0.45 g of 2-thienylacetyl chloride, to afford 0.71 g of the title compound melting at 215° C. (dec.).

Sources & evidence

ORD record
ord-e092e6f993364bb2b396931b6ebf815a
Source dataset
uspto-grants-1993_12
Patent number
US05270327

Reaction notes

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