1-Methyl-3-(pyrrolidin-1-ylmethyl)piperazine trihydrochloride → 4-Methyl-1-(3-oxoindan-1-carbonyl)-2-(pyrrolidin-1-ylmethyl)piperazine dihydrochloride

HRID 326736Notes

Reaction equation

HRID 326736 reaction equation
[ClH:1].Cl.Cl.[CH3:4][N:5]1[CH2:10][CH2:9][NH:8][CH:7]([CH2:11][N:12]2[CH2:16][CH2:15][CH2:14][CH2:13]2)[CH2:6]1.[O:17]=[C:18]1[C:26]2[C:21](=[CH:22][CH:23]=[CH:24][CH:25]=2)[CH:20]([C:27]([Cl:29])=[O:28])[CH2:19]1>C(N(CC)CC)C>[ClH:29].[ClH:1].[CH3:4][N:5]1[CH2:10][CH2:9][N:8]([C:27]([CH:20]2[C:21]3[C:26](=[CH:25][CH:24]=[CH:23][CH:22]=3)[C:18](=[O:17])[CH2:19]2)=[O:28])[CH:7]([CH2:11][N:12]2[CH2:16][CH2:15][CH2:14][CH2:13]2)[CH2:6]1

Participants

4

Reactant 2

HCID 189151091-Methyl-3-(pyrrolidin-1-ylmethyl)piperazine trihydrochlorideHCID 218205193-Oxoindan-1-carbonyl chloride

Product 1

HCID 189151494-Methyl-1-(3-oxoindan-1-carbonyl)-2-(pyrrolidin-1-ylmethyl)piperazine dihydrochlorideYield 31.9%

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Procedure

The procedure described in Example 24 was repeated, but using 3.21 g of 1-methyl-3-(pyrrolidin-1-ylmethyl)-piperazine trihydrochloride, 6.9 ml of triethylamine and 4.5 g of 3-oxoindan-1-carbonyl chloride, to afford 1.45 g of the title compound, melting at 252°-255° C. (dec.).

Sources & evidence

ORD record
ord-50cd92cf3cc0418ab89a90207c379706
Source dataset
uspto-grants-1993_12
Patent number
US05270327

Reaction notes

Loading…