2-Pyrrolidin-1-ylmethyl-piperidine → 1-(5,6-Dichloroindan-1-carbonyl)-2-(pyrrolidin-1-ylmethyl)piperidine hydrochloride

HRID 326752Notes

Reaction equation

HRID 326752 reaction equation
[N:1]1([CH2:6][CH:7]2[CH2:12][CH2:11][CH2:10][CH2:9][NH:8]2)[CH2:5][CH2:4][CH2:3][CH2:2]1.[Cl:13][C:14]1[CH:15]=[C:16]2[C:20](=[CH:21][C:22]=1[Cl:23])[CH:19]([C:24](Cl)=[O:25])[CH2:18][CH2:17]2>>[ClH:13].[Cl:13][C:14]1[CH:15]=[C:16]2[C:20](=[CH:21][C:22]=1[Cl:23])[CH:19]([C:24]([N:8]1[CH2:9][CH2:10][CH2:11][CH2:12][CH:7]1[CH2:6][N:1]1[CH2:5][CH2:4][CH2:3][CH2:2]1)=[O:25])[CH2:18][CH2:17]2

Participants

3

Reactant 2

HCID 27605412-Pyrrolidin-1-ylmethyl-piperidineHCID 189151665,6-Dichloroindan-1-carbonyl chloride

Product 1

HCID 189150451-(5,6-Dichloroindan-1-carbonyl)-2-(pyrrolidin-1-ylmethyl)piperidine hydrochlorideYield 32.6%

Procedure

From 1.18 g of 2-(pyrrolidin-1-ylmethyl)piperidine, and 1.87 g of 5,6-dichloroindan-1-carbonyl chloride. 0.51 g of the title compound was obtained melting at 245°-250° C. using a procedure similar to that in Example 1.

Sources & evidence

ORD record
ord-ca0e569e6bd642e9810dd8b46d458dd6
Source dataset
uspto-grants-1993_12
Patent number
US05270327

Reaction notes

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