Hydrochloric Acid → HCID 18915022, compound

HRID 326754Notes

Reaction equation

HRID 326754 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][S:11][CH2:10][CH:9]1[C:14]([N:16]1[CH2:20][CH2:19][CH2:18][CH2:17]1)=[O:15])=O)(C)(C)C.O1CCOCC1.[ClH:27]>CO>[ClH:27].[N:16]1([C:14]([CH:9]2[CH2:10][S:11][CH2:12][CH2:13][NH:8]2)=[O:15])[CH2:17][CH2:18][CH2:19][CH2:20]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 157301454-(t-Butoxycarbonyl)-3-(pyrrolidine-1-carbonyl)thiomorpholine

Product 1

HCID 18915022HCID 18915022, compoundYield 96%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

4-(t-butoxycarbonyl)-3-(pyrrolidine-1-carbonyl)-thiomorpholine (3.2 g) was dissolved in 50 ml of methanol. A 4N 1,4-dioxane solution of hydrogen chloride (13.1 ml) was added, and the solution was condensed to yield white crystals. These crystals was recrystallized from ethanol and diethyl ether to give 2.47 g (96%) of 3-(pyrrolidine-1-carbonyl)-thiomorpholine monohydrochloride.

Workup

  1. customcondensed
  2. customto yield white crystals
  3. customThese crystals was recrystallized from ethanol and diethyl ether

Sources & evidence

ORD record
ord-97335f0bae474d37a82b7e1fe0a4b6b9
Source dataset
uspto-grants-1993_12
Patent number
US05270327

Reaction notes

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