反应详情

A mixture of 163.8 mg (0.7 mmol) 2-Chloro-5-methanesulfonyl-benzoic acid in 2 ml pyrrolidine was heated for 16 h to 100° C. After evaporation of all volatiles the residue was taken up in 2 ml methanol/formic acid 3/1 and subjected to reversed phase HPLC purification eluting with an acetonitrile/water gradient to yield after evaporation of the product fractions 143.4 mg (77%) of the title compound. MS (m/e): 268.1 (MH−, 100%).

1. temperaturewas heated for 16 h to 100° C
2. customAfter evaporation of all volatiles the residue
3. customsubjected to reversed phase HPLC purification
4. washeluting with an acetonitrile/water gradient
5. customto yield
6. customafter evaporation of the product fractions 143.4 mg (77%) of the title compound