Tetrabutylammonium Hydroxide → HCID 131718268, compound

HRID 326808Notes

Reaction equation

HRID 326808 reaction equation
[Cl:1][C:2]1[CH:11]=[CH:10][C:9]([OH:12])=[C:8]2[C:3]=1[C:4]([N:13]([CH3:15])[CH3:14])=[N:5][CH:6]=[N:7]2.[OH-].[CH2:17]([N+:21]([CH2:30][CH2:31][CH2:32][CH3:33])([CH2:26][CH2:27][CH2:28][CH3:29])[CH2:22][CH2:23][CH2:24][CH3:25])[CH2:18][CH2:19][CH3:20]>ClCCl>[CH2:30]([N+:21]([CH2:17][CH2:18][CH2:19][CH3:20])([CH2:22][CH2:23][CH2:24][CH3:25])[CH2:26][CH2:27][CH2:28][CH3:29])[CH2:31][CH2:32][CH3:33].[Cl:1][C:2]1[CH:11]=[CH:10][C:9]([OH:12])=[C:8]2[C:3]=1[C:4]([N:13]([CH3:15])[CH3:14])=[N:5][CH:6]=[N:7]2

Participants

4

Reactant 2

HCID 2723671Tetrabutylammonium HydroxideHCID 18952375HCID 18952375, compound

Product 1

HCID 131718268HCID 131718268, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A solution of 5-chloro-4-(dimethylamino)-8-quinazolinol (0.45 g, 2.01 mmol) and a 40% tetrabutylammonium hydroxide solution (1.0 go 1.54 mmol) in dichloromethane is stirred for 10 minutes at room temperature, washed sequentially with water and brine, dried over Na2SO4 and concentrated in vacuo to obtain the title product as a green oil, 0.35 g, which is identified by 1HNMR spectral analysis.

Workup

  1. washwashed sequentially with water and brine
  2. dry with materialdried over Na2SO4
  3. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-6dc2b20936bf42778c167992793ebe10
Source dataset
uspto-grants-1993_12
Patent number
US05270466

Reaction notes

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